Research Team


Dr. Valérie Chappe, PhD
Assistant Dean, Graduate & Post-doctoral studies - Faculty of Medicine
Atlantic Cystic Fibrosis Translational Research Group (Leader)
Professor, Cystic Fibrosis Canada Researcher
Phone:  902-494-2995
Email:  valerie.chappe@dal.ca

Professor. 06/2019
Department of Physiology & Biophysics, Dalhousie University - Faculty of Medicine, Halifax, NS, Canada.

Assistant Dean. 01/2018-Present
Graduate & Post-doctoral studies, Dalhousie University - Faculty of Medicine, Halifax, NS, Canada.

Associate Professor. 07/2010-06/2019
Department of Physiology & Biophysics, Dalhousie University - Faculty of Medicine, Halifax, NS, Canada.

Assistant Professor.01/2005-03/2010
Department of Physiology & Biophysics, Dalhousie University - Faculty of Medicine, Halifax, NS, Canada.
CIHR New Investigator In Cystic Fibrosis Basic Science.

Post-Doctoral Fellow. 09/1999-12/2004.
Department of Physiology, McGill University, Montreal, Qc, Canada.

PhD in Cellular Biology. 07-1999.
University Of Provence, Marseille, France.

MSc in Cellular Biology, Molecular Biology & Microbiology - Major in Genetics & Development. 07/1996.
University of Provence, Marseille, France.

MSc, Major in Immunology. 07/1994.
University of Aix-Marseille II, Marseille, France.

BSc of Cellular Biology & Physiology. 07/1993.
University of Aix-Marseille II, Marseille, France.


Frédéric Chappe
Lab Manager, since 2005
Email:  frederic.chappe@dal.ca

Audrey Li
Research Associate (part-time)
Email:  audrey.li@dal.ca

Mansong Li
Research Associate
Email:  mansongli@gmail.com

Poliana (Anna) Semaniakou, MSc
PhD Student: 10/2015-present
Project: VIP secretion and CF development.

Maral Aali, MSc
PhD Student: (Supervisors: Dr Christian Lehmann and Dr Valerie Chappe)
Funding: Killam pre-doctoral scholarship.
Project: Iron chelation and inflammation.

Nazli Alizadeh-Tabrizi
MSc Student: 09/2019-present
Funding: NSGS Scholarship and Department of Physiology & Biophysics entrance award.
Project: Intravital Microscopy of the mouse Lung to assess inflammation.

Brett Allen
BSc in Medical Sciences
Experiential Learning in Medical Sciences and Volunteer. 2019-2020

Jamie Paton
BSc Honours in Medical Sciences.
Undergrad Volunteer and Honours thesis:Histological evaluation of Cystic Fibrosis progression in CF mice.
Research Associates/Technicians, Graduate Students, BSc Honours, Undergrad Summer & Volunteer Research

Research Associates/Technicians


Dr. Mansong Li
Research Associate, 2011-2013

Hemei Tang
Research Technician (2006-2008).
Current Position: Nursing Student.

Graduate Students


Diogo daRocha Poroca, MSc
PhD Student: 09/2013-08/2019
Project: Physiological role and functional significance of PKC phosphorylation in CFTR domains interaction.
External funding: Science Without Borders Scholarship - Brazil.



Walaa Alshafie
MSc Student 09/2011-12/2013
Project: Regulation of the CFTR protein by the Vasoactive Intestinal Peptide.
MSc 12/2013
Thesis Title: Regulation of CFTR endocytosis by the vasoactive intestinal peptide: role of PKCε

Dustin Conrad, M.Sc (2011)
Thesis: Increased VIP receptor expression mediates CFTR membrane localization in response to VIP treatment in VIP Knockout mice.
Previous work in the lab: Biology Honours, 05/2008-05/2009. "Functional study of rare mutations in the CFTR protein."
Funding: NSERC - Master Award (2010-2011)
Current Position: Medical Student, Dalhousie Medical School.

Noha Amer, M.Sc (2010)
Thesis: Serine 686 is critical for PKA-Induced Association of the R Domain with other regions of CFTR.
Previous work in the lab: Research Technician: Sept-Dec 2010

Nicole Alcolado, M.Sc (2010)
Thesis: Regulation of CFTR membrane localization by Vasoactiva Intestinal Peptide (VIP).
Previous work in the lab: Honours Thesis (May 2008), "Identifying G proteins involved in Vasoactive Intestinal Peptide (VIP) correction of Cystic Fibrosis (CF) disease causing mutation: delF508."
Funding: NSERC-USRA: Summer Award(2008). NSHRF: Master Award(2008-2010).
Current Position: Medical Student, Dalhousie Medical School.

BSc Honours


Sarah Brothers
BSc. Med. Sci. Honours, 2017-2018
Honours thesis: Vasoactive Intestinal Peptide and Insulin concentration in CF and WT mice lung, pancreas and duodenum

Alina Cheng
BSc Volunteer, 2016-

Grayson Gould
BSc. Med. Sci. Honours, 2016-

Jennifer Wu
BSc Volunteer, 2017-

Isobel MacKenzie
BSc Honours, 01/2014-2016
Project: Establishing CF progression in patients with rare CFTR mutations.

Breagh Matheson
BSc Honours, 04/2015
Thesis: Differences in VIP secretion between CF and Wildtype mice exoctine tissues.

Grace Jothiraj
BSc Honours, 04/2015
Thesis: The mechanism by which VIP rescues F508del-CFTR in JME/CF15 cells.

Jiyoung Song
BSc Honours, 05/2013-04/2014
Thesis: Characterization of mCFTR antibodies.

Andrew Kilby
BSc Honours, 05/2013-04/2014
Thesis: Role of PKC phosphorylation in CFTR domains interaction.

Valerie Paquette
BSc Honours, 2013/5
Thesis: The rare mutation P64L confers a dominant mild phenotype.

Patrick Boivert
BSc Honors, 09/2011-04/2012
Thesis: Domain interactions in the CFTR chloride channel.
Current position: Grad Student (McGill University)

Undergrad Summer & Volunteer Research


Mehrsa Zahiremami
Summer Research: 2014/2015
Project: CFTR expression & VIP secretion.

Marylin Min Ju Kwak
Undergrade Volunteer, 06/2013-07/2013
Project: VIP-KO mice histology.

Shannon Vandriel
Undergrade BSc Volunteer, 12/2011-05/2013
Project: Mapping of the mouse nasal cavity.

TianDia Gao
International Medical Student. Summer research, 07-08/2012
Thesis: Histology of VIP-KO mice exocrine tissues.

Fanny Rousseau, MD/Master 1 (2010)
International Exchange Student: Université de Poitiers, France.
Project: Isolation of mice tracheas and primary culture of epithelial cells for ex-vivo study of CFTR regulation by VIP.
Current Position: Medical Student, Université de Poitiers, France.

Nada Ismaiel
Summer Student, 05/2009-09/2009.
Project: Establishing stable cell lines expressing recombinant mutated CFTR proteins.
Current Position: Medical Student, Dalhousie Medical School.

Sara Rafferty
Science Co-op & Honour Student. Biology Honours, Acadia University.
Summer Studentship, 2007 & 2008.
Honours Thesis(2008): ΔF508-CFTR stability at the apical membrane of human nasal epithelial cells.
Funding: CCFF (Canadian Cystic Fibrosis Foundation)

Faiza Siddiqi
Biology Honours.
Honours Thesis(2008): P67L Mutated CFTR: Molecular Analysis of Cellular Localization and Phenotypic Analysis of Cystic Fibrosis Patients in the Maritimes.
Funding: NSERC- USRA: Summer Award (2007).
Current Position: Dentistry Student, Dalhousie University.

Mathew Kiberd
Summer Student, 05-09/2006
Project: Regulation of wild-type and ΔF508-CFTR channels by PKC

Gage Seavilleklein
Summer Student, 05-09/2006
Funding: NSERC-USRA. Summer award. 2006.
Project: Characterization of the 7CA-CFTR Chloride Channel